Antagonists

Season 1

 * Main Villains: Peter Hale (The Alpha), and Kate Argent
 * Secondary Villains: Chris Argent, Jennifer (Peter’s nurse)

Season 2

 * Main Villain: Matt, Jackson Whittemore (The Kanima)
 * Secondary Villains: Gerard Argent and Victoria Argent

Season 3A

 * Main Villain: Jennifer Blake (The Darach) and Deucalion
 * Secondary Villains: Peter Hale, and the Alpha Pack

Season 3B

 * Main Villain: Nogitsune (Void Stiles)
 * Secondary Villain: Oni, Severo Calavera

Season 4

 * Main Villains: Meredith Walker (The Benefactor), Kate Argent, and the Berserkers
 * Secondary Villains: Brunski, The Mute, Garrett, Violet, Peter Hale, and The Chemist

Season 5

 * Main Villains: Dread Doctors and La Bête du Gévaudan
 * Secondary Villains: Theo Raeken, The Desert Wolf, Donovan Donati and Tracy Stewart

Season 6A

 * Main Villains:Ghost Riders
 * Secondary Villains: Garret Douglas

Season 6B

 * Main Villains: Anuk Ite, Gerard Argent and Tamora Monroe
 * Secondary Villains: Kate Argent, all of the citizens, Nolan and Gabe